Shamanic modalities have been used in traditional cultures for hundreds of years and are now increasingly popularized in the industrialized advanced countries as well. Today, there is also great interest and study of the use of man-made psychedelics substances in healing. The principles on which such modalities are based have now been validated by Western scientific approaches such as psychoneuroimmunology and interpersonal neurobiology. While no panacea, shamanic and psychedelic treatments can offer an important and, frequently, transformative, approach to treatment. Clinical pearls here will emerge from the interactive portion of this workshop and include understanding the difference between various shamanic modalities for various clinical conditions.